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KMID : 0359319960360030571
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Korean Journal of Veterinary Research
1996 Volume.36 No. 3 p.571 ~ p.575
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Determination of sulfamethazine residues in liver , kidney and muscle according to the time lapsed after oral administration of sulfamethazine sodium to rats
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Abstract
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Sulfamethazine sodium was orally administrated to Sprague Dawley female rats(body weight : 200-250g) with the sonde caude at the dose of 20mg of sulfamethazine sodium per 100g of body weight for 3 days to investigate the depletion rate of the drug from liver, kidney and muscle of rat.
The results obtained were summarized as follows;
1. The mean concentrations of sulfamethazine in liver according to the time lapsed after oral administration of the sulfamethazine sodium were decreased from 1.27ppm at day 1 to 0.28ppm at day 4.
2. Sulfamethazine concentrations in kidney according to the time lapsed after oral administration of the sulfamethazine sodium were decreased from 0.77ppm at day 1 to 0.12ppm at day 4.
3. The mean concentration of sulfamethazine in skeletal muscle according to the time lapsed after oral administration of the sulfamethazine sodium was at or below 0.09ppm within 4 days after withdrawl of medicated solution.
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